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70 The amino acid change at position 495 impairs SOCS2 binding and leads to a reduced downregulation of the receptor

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Effects of GLP-1RAs on oxidative stress and mitochondrial function In patients with diabetes, chronic hyperglycemia can lead to excessive production of ROS and consequent imbalance in redox status in brain tissues, which may play an important role in the pathogenesis of ischemic stroke [85]

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370 Notably, the NATALEE trial included 40% of patients who were excluded from the MonarchE study due to having stage II and stage III N0 disease, making it a more comprehensive clinical trial of CDK4/6 inhibitors in early breast cancer to date

In vivo autoxidation of dopamine in guinea pig striatum increases with age