However, aging, stress, and disease decrease your glutathione levels, leading to a host of health issues
Azran C, Porat D, Fine-Shamir N, Hanhan N, Dahan A
McCarty noted that this recommendation was not based on empirical data
The American Association of Clinical Endocrinologists/American College of Endocrinology consensus statement also recommends either a GLP-1RA or SGLT2i as a preferred treatment option (either as first-line or, more typically, second-line treatment after metformin) over alternative options such as a dipeptidyl peptidase-4 inhibitor, a thiazolidinedione (TZD), or a sulfonylurea (SU), for patients with T2D and ASCVD, stage 3 CKD, or heart failure with reduced ejection fraction [2]
Zhang L, Tian J, Diao S, Zhang G, Xiao M, Chang D
Glutathione and the Evolution of Enzymes for Detoxication of Products of Oxygen Metabolism