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BMS picked up the drug in its December 2023 acquisition of Karuna
NAC, a precursor for glutathione (GSH) synthesis, is a small molecular amino acid derivative
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Total semaglutide used during this phase: 2.0 mg (4 injections of 0.50 mg) Cumulative total through week 8: 3.0 mg Weeks 9 to 12: the therapeutic threshold (1.0 mg per week) This is where the protocol gets serious
The net result of this mechanism of action is that overexpression of melanin is attenuated which means less hydrogen peroxide production and localized hyperpigmentation
Bibcode:2023FrPH...1155706M
(2023): Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes
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