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By activating GLP-1 receptors in the hypothalamus and other brain regions involved in satiety, semaglutide reduces hunger signals and enhances the feeling of satisfaction after eating smaller amounts of food

Several randomized controlled clinical trials conducted by Malaguarnera et al

Its also approved for children aged 12 or older weighing over 60 kg (132 lbs)

In a recent phase III clinical trial for overweight patients without diabetes, using Semalutide 2.4mg once a week, after 68 weeks of treatment, the body weight decreased by 14.9%, compared with 2.4% in the control group

When one-third of participants were randomized to take a placebo instead of semaglutide for 48 months, they regained 7 percent of the weight they lost

10.1038/269615a0 240 ZhangY.ProencaR.MaffeiM.BaroneM.LeopoldL.FriedmanJ