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An increased risk of amputations was reported in the CANVAS Program trial but has not been demonstrated in any other clinical trial nor was there any signal of this issue in a meta-analysis involving 57,713 participants [54]

At a high level, the decision usually comes down to what youre actually trying to change

Semaglutide, found in both Ozempic and Wegovy, helps regulate appetite and food intake, with Wegovy specifically approved for weight management

Retatrutide GLP-1 / GIP / Glucagon Triple Agonist in vitro research use only

Common side effects of GLP-1 include nausea, diarrhea, constipation, reduced appetite, and mild fatigue these typically resolve within the first few weeks as your body adjusts to tirzepatide