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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Nature 445 , 881885 (2007)

Whilst their primary therapeutic targets are glycaemic control and weight reduction, their brain-mediated effects contribute significantly to clinical outcomes and adverse effect profiles

This ubiquitous protease is expressed in several tissues, including pancreatic -cells, and cleaves the amino-terminal dipeptide at the penultimate position with either L-proline or L-alanine (GLP-1), limiting the clinical utility of GLP-1 in T2DM patients, particularly its insulinotropic actions (Figure 1), lacking the His-Ala dipeptide, have 100-fold less affinity towards GLP-1R

This space retains a tiny amount of solution that does not get injected

Trying to override this rhythm with a daytime dose can be less effectiveor even work against your goals