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Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated significant weight reduction in adults with obesity, and Phase 3 trials are ongoing (ClinicalTrials.gov)

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The practical result is a once-daily pill that can be taken at any time without food or water restrictions, available since April 2026 at $149 per month for self-pay patients

Disabling CBP/p300-binding to NRF2 broadly attenuated NRF2 transcriptional activity resulting in an altered metabolic (depletion of glutathione) and lipidomic (specific depletion of triglycerides) cellular landscape