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The LEADER trial (liraglutide) and SUSTAIN-6 trial (semaglutide) enrolled thousands of patients and measured cardiovascular outcomes including thrombotic events
The GSH content existing in millimolar concentrations varies among different organs
Dexamethasone, in particular, has been linked to metabolic disturbances such as hyperglycemia, insulin resistance, hepatic steatosis, and the development of type II diabetes (Madamsetty et al., 2022)
The concern is that unmetabolised folic acid may compete with naturally occurring folate for enzyme binding sites, potentially impairing normal folate-dependent metabolism
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