Prinz, W

If youre a clinician considering microdosing: Be explicit: We dont know exactly how or why this might work at this dose Consider it especially for: Normal-weight patients with metabolic dysfunction Patients who cant tolerate higher doses Conditions with strong mechanistic rationale (PCOS, autoimmune disease, addiction) Monitor objectively: weight and body composition, waist circumference, labs, symptom scores, not just subjective reports Track patients who dont lose weight but report benefits - these are your most interesting cases Document everything, contribute to registries If youre a patient considering microdosing: Understand that benefits without weight loss are reported but not proven Know that you might be benefiting from small amounts of visceral fat loss that dont show on your scale Be skeptical of your own subjective improvement (placebo is real) Know that all medications come with possible side effects Work with a clinician who will help you figure out if its actually working If youre a researcher: Please study the minimal effective dose Use imaging to measure visceral fat, not just scale weight Design studies in normal-weight metabolically unhealthy individuals Compare weight-matched groups to isolate non-weight-loss effects My opinion

At RR Wellness, we assess your goals and health history to determine which option is best for you
A 2025 analysis found semaglutide users more likely to receive a hair-loss diagnosis than those on other weight-loss medications
Depression that correlates with obesity: A therapist skilled in treating depression can address the emotional challenges patients may face
Initial lab test: Included when medically necessary If your provider determines labs are needed before starting treatment, MEDVi partners with Quest Diagnostics for easy access