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Common adverse effects are predominantly gastrointestinal and include: Nausea (reported in 1544% of patients) Vomiting (524%) Diarrhea (830%) Constipation (1124%) Abdominal pain (520%) These effects are typically most pronounced during initial treatment and dose escalation, often diminishing over several weeks as tolerance develops
Many of the new complaints include gastroenterologist assessments and imaging that confirm delayed gastric emptying
Berberine may also slow intestinal motility, which can worsen nausea and bloating, two of the most common side effects reported with GLP-1 therapies
Professor Richard McManus (University of Oxford) for help with data presentation and interpretation
Individuals with a "non-responsive" genetic score were up to 50% more likely not to lose weight at all on the same medications, at the same doses
In the end, its different methods to do the same thing, says Pichamol Jirapinyo, a bariatric endoscopist at Brigham and Womens Hospital in Boston and a cofounder of Bariendo, a network of 10 nonsurgical weight-loss clinics across the United States
