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In: LszlBJulianaOEdson MauroS, editors
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However, these medications do not directly target thyroid function or autoimmune processes, which is an important distinction when considering their potential role in Hashimoto's disease management
The bigger factor is typically dose and titration speed rather than the specific medication chosen
Semaglutide works by: Enhancing insulin secretion in response to elevated blood glucose levels Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , leading to prolonged feelings of fullness Acting on appetite centres in the brain , reducing hunger and food intake It is this combination of delayed gastric emptying and reduced appetite that contributes to weight loss in many patients
(Oral Wegovy was approved in December 2025, but requires fasting before and after each dose.) In clinical trials, patients on the highest dose lost approximately 27 lbs (12.4% body weight) over 72 weeks
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