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It increases GLP-1 and another hormone called glucose-dependent insulinotropic polypeptide (GIP) This means it works in two ways while semaglutide only mimics GLP-1 hormones, tirzepatide also mimics GIP hormones

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4 to 5 weeks Steady-state exposure is achieved following 4 to 5 weeks of administration Following oral administration, maximum concentration of RYBELSUS is reached after 1 hour Watch to learn more about the RYBELSUS method of absorption You may also be interested in: Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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