doi: 10.1089/cyber.2023.0311, 41
Mechanistic diagram of the Sirt1--PGC1- mitochondrial pathway that mediates the chemical resistance of DLBCL cells and blocks the mitochondrial energy metabolism pathway in overcoming Sirt1-mediated drug-resistance.
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Dosagens nos estudos animais: Na grande maioria dos estudos pr-clnicos, as doses utilizadas em ratos situam-se entre 10 g/kg e 10 ng/kg de peso corporal, administradas por via intraperitoneal ou oral
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The acetylated form can cross the blood-brain barrier and is therefore considered the "L-carnitine of the brain"