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This is because the citrate (citr), which is formed by condensation of acetyl Coenzyme A with pre-existing oxaloacetate in the TCA cycle loses two molecules of CO 2 during the turn of the cycle, which leads to re-generation of oxaloacetate

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Ibuprofen and Its Mechanism of Action Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) known for its effectiveness in relieving pain, reducing inflammation, and lowering fever

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doi: 10.1016/j.addbeh.2014.01.006 12 WilcoxCECalhounVDRachakondaSClausEDLittlewoodRAMickeyJet al