Tied events were handled using the Exact method 54,55 , if possible, or Efrons method 56 , if not
the ceiling is awareness
Current Topics in Medicinal Chemistry, 7 (11), 1098-1106
injection in the vein (IV) or intramuscular (IM) every 2 weeks
The UK SmPC for Wegovy advises healthcare professionals to monitor patients for depression or suicidal thoughts and to consider discontinuing treatment if these occur
Indications: FDA approved: Type II diabetes - monotherapy or combination therapy Can be combined as adjunct therapy with other hypoglycemics including metformin, thiazolidinediones, or insulin regimens (Dungan & DeSantis 2015) Because it does not work when your blood sugar is low, it is unlikely to produce dangerous levels of hypoglycemia has been observed in clinical trials (in contrast to GLP-1 incretin mimetics, such as exenatide, which produce moderate weight loss)