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Biochem Biophys Res Commun 733:150597

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What to do with leftover medication from the old concentration When you switch concentrations mid-vial, you may have leftover medication in the old vial

Reconstitute using sterile bacteriostatic water or an appropriate laboratory buffer Add solvent slowly along the vial wall to minimize foaming during dissolution Avoid vigorous agitation, shaking, or vortexing of the peptide solution Gently swirl or invert the vial until the peptide is fully dissolved Store reconstituted solutions at 3646 F (28 C) during short term use Prepare aliquots where appropriate to reduce repeated freezethaw exposure Careful reconstitution practices help maintain peptide stability and support reliable experimental conditions

Therefore, while the detrimental effect of lapaquistat on Cryptosporidium sexual stage development is most pronounced, the drug appears to also stall asexual parasite development prior to sexual stage commitment

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