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GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks

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For reliable background on vitamin B12, see the NIH fact sheet: Vitamin B12 - Health Professional Fact Sheet

Certain parts of the body absorb more steroid than others and thus carry higher risks: Face (especially around the eyes and mouth) Neck Genital area Skin folds (groin, armpits, elbows, behind knees) In these areas, even mild steroids should be used very sparingly and with medical guidance

Once weekly or daily, as prescribedtiming depends on the drug