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Clinicians should nonetheless be aware of the broader metabolic receptor context when evaluating GHS-R1a agonists in patients with metabolic comorbidities

Severe Depression or Suicidal Ideation : Given reports linking GLP-1 RAs to increased risks of depression and suicidal behaviour, patients with these conditions require meticulous evaluation

Retatrutide's side effect profile, dominated by gastrointestinal symptoms in phase 2 trials, is substantially attenuated by starting at a low dose and increasing gradually over weeks

Ozempic is only available as a brand-name drug

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