They have not been evaluated by the FDA for safety, efficacy, or quality
Many patients find long-term therapy affordable, especially compared to weight regain costs and health complications
Clinicians and patients need to always balance benefit and harm of treatments in light of their alternatives
Glucagon-like peptide 1 receptor (GLP-1R), on the other hand, is primarily expressed in the pancreas, gut, central nervous system, and also found in other tissues like the heart, kidneys, and lungs
Lerner, A., Jeremias, P., Neidhofer, S
Preclinical studies have found that Ex-4 significantly upregulates Sirt3 expression in glioblastoma by activating the GLP-1R, which subsequently inhibits the growth, migration, invasion, and epithelial-mesenchymal transition of glioma cells [87]