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This consistency, together with non-overlapping mechanisms, indicates that the two classes act independently rather than redundantly

Patients should contact their healthcare provider promptly if they experience: Severe, persistent abdominal pain that worsens or differs from typical bloating Inability to pass gas or have bowel movements (possible obstruction) Persistent vomiting that prevents adequate hydration or medication adherence Unintentional weight loss beyond expected therapeutic effects Blood in stool or black, tarry stools Fever accompanying gastrointestinal symptoms Right upper quadrant pain or yellowing of skin/eyes (possible gallbladder disease) Severe constipation with abdominal distension (possible ileus/obstruction) Signs of dehydration (excessive thirst, dark urine, dizziness) These symptoms may indicate complications such as pancreatitis, gallbladder disease, bowel obstruction, or acute kidney injuryall noted in FDA prescribing information as potential risks

Yabe D, Nakamura J, Kaneto H, Christensen SB, Navarria AM, Gislum M, Inagaki N

Therefore, we conducted sensitivity analyses to determine whether baseline HbA 1c or prior metformin treatment were mediating factors

That way, it is easier to keep using this treatment for the best results