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Retatrutide dosing protocol Retatrutide uses a different titration approach, reflecting its greater potency and triple-receptor activity: Weeks 1-4: 1 mg once weekly (starting dose) Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Week 17 onward: 8-12 mg once weekly (maintenance dose) Some trial protocols use a slightly modified schedule, escalating every four weeks with dose increases of approximately double at each step