The maximal efficacy obtained at any single concentration of modulator is plotted for e , LSN3160440 and k , BETP
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The copper ionophore disulfiram has been used for decades with sporadic anticancer activity, while its systematic evaluation in AML is still confined to an early-stage trial, highlighting a significant translational challenge for the cuproptosis pathway (214)
Microdosing involves using substantially lower doses than standard therapeutic regimens, falling outside approved prescribing guidance
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58.3% in control group at 3 weeks) and earlier radiological improvement by significantly reducing the cavity surface area and increasing glutathione peroxidase levels in the NAC group (72)