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To generate expression plasmids, wild-type and mutant CDSs of Cas9, TRIM37, TRIM28, and AP2 were ligated into PiggyBac-CAG, pcDNA-CMV, or pACYC-Ub-HA plasmids
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The effects are unclear, but medicines acting in the same way can lower DHT, too
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In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]
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