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In neurons, Grx has a protective effect on redox-sensitive enzymes and ion channels, meaning that its dysfunction is implicated in several neurodegenerative disorders involving protein misfolding and redox signaling dysregulation (Ogata et al., 2021)

Patients often report a gradual but positive change over weeks of therapy

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Comparison of the prevalence of deficient riboflavin status among these studies is often difficult because the method of EGR AC assessment has not been standardized and as shown in a systematic evaluation of the existing methods, variations in the laboratory protocols applied in various studies could produce significantly different results (Hill et al., 2009)

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