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It results in a higher percentage of degraded RBCs, thereby reducing the RBC count and causing anemia during sepsis (eryptotic RBCs were degraded and cleared from circulation) [202, 230, 380]
There is a pregnancy exposure registry for individuals who use OPZELURA during pregnancy
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Randomization and administration of investigational drug Participants ( n = 39, Intention to Treat (ITT) population) with severe or moderate IPTB risk were randomized to receive either a high-dose NAC regimen or placebo per os , preceded by an initial intravenous ( iv )-infusion in the subgroup of severe IPTB (Fig
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