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Furthermore, studies reveal that KYN pathway metabolites, particularly quinolinic acid (QA), are significantly elevated in CKD patients due to altered tryptophan metabolism by gut microbiota

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doi: 10.1007/s10354-015-0344-y 62 DinarelloCA

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The study tested the effect of a small dose of exenatide in mice, starting treatment at about 11 months of age and continuing for around 30 weeks

Authors suggested that total saponins of red ginseng affected the NGF expression in the periphery rather than centrally of brain [90]