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The lower rate of non-CV deaths was because of lower infectious deaths, in particular COVID-19related deaths, suggesting that semaglutide has a favorable outcome in terms of mortality across a broad population of patients with CV disease and obesity ( Besides HbA1c and weight reduction, the criteria for initiating a GLP-1 RA with proven CV benefit should include an estimation of the patient's CV risk

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A 2012 meta-analysis published in the Journal of Ethnopharmacology reviewed 14 randomized trials involving berberine supplementation