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The cold constricts local blood vessels, which also reduces bruising risk

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Insurance coverage is inconsistent, and long-term monthly expenses can become enormous

It was also demonstrated to downregulate Fe 2+ , cyclooxygenase 2 (COX2), and upregulate Nrf2 and its downstream related ferritin (including SLC7A11, GPX4, HO-1) expression to reduce lipid peroxidation and inhibit retinal ferroptosis (Song et al., 2024)

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