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GLP-1s, however, may also exert direct hormonal effects as GLP-1 receptors can be found across the hypothalamus-pituitary-ovarian (HPO) axis and influence gonadotropin release and follicle development

Clinical Implementation Challenges Patient Selection and Individualization The importance of individualized dosing and patient assessment to optimize safety and efficacy [68] [69] [70] represents a key implementation challenge

The timeline for side effects typically follows a predictable pattern, peaking early and fading

R.WolfgeherD.et al (2014)

Valenzuela A, Aspillaga M, Vial S, Guerra R (1989)

very high doses, non-medical settings)