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Shift from depolarizing to hyperpolarizing glycine action in rat auditory neurones is due to age-dependent Cl regulation

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Mutation of allosteric hot spot residues alter the allosteric communications In order to examine how the triangular allosteric network responds to the mutations of key residues, we have prepared three GDH mutants in silico using Chimera rotamers tools 29 GDH Ser441Leu , GDH Arg217Cys , and GDH Gly376Asp

Involvement of germ cell apoptosis in the induction of testicular toxicity following hydroxyurea treatment

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At pH value less than 6.5, the decrease in the enzymatic rate of product formation might be attributable to acid de-naturation of protein thereby reducing its catalytic capability