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Finally, -butyrobetaine hydroxylase catalyzes the hydroxylation of - N -trimethylaminobutyrate to generate L-carnitine, requiring Fe 2+ and ascorbate

doi: 10.1007/978-3-319-22822-8_15 488 RichmanSMorrisMCBroderickGCraddockTJAKlimasNGFletcherMA

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A decrease in IGF-1 leads to reduced activity of the protein kinase B (AKT)/mTOR pathway, which in turn activates FOXO1 (192)