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Clinical trials have demonstrated its remarkable ability to reduce body weight by enhancing satiety and reducing calorie intake

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Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis and FAO 81 resulting in defective cell metabolism and carcinogenesis 82 directly targeting key enzymes or transcription factors as oncogenes and tumor suppressors 81 as shown in Table 1

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Further analysis via western blot and DNA fragmentation ELISA analysis showed that TNF addition increased PARP cleavage (a marker of apoptosis