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SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice

NICE NG246 (2025) recommends lower BMI thresholds (27.5 instead of 30, and 24.5 instead of 27) for South Asian, Chinese, Other Asian, Middle Eastern, Black African, and African-Caribbean backgrounds, because type 2 diabetes risk rises at lower BMIs in these populations 3,5

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By month two the belly started responding