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During follicular development and luteinization, granulosa cells and oocytes undergo substantial changes in lipid uptake and synthesis

PMID: 31409014

An important nuance: while the trials did not publish detailed BMI-stratified results in their primary papers, the data consistently shows that higher baseline BMI correlates with greater absolute weight loss in kilograms, while lower baseline BMI correlates with greater percentage weight loss

The lethal concentration (LC 50 ) for HThF cells was ~ 1 M, while the LC 50 for the PTC cell lines was substantially less (0.050.5 M)

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Crucially, this stasis exacerbates a process called enterohepatic recirculation