These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (71)
So they're tracking their energy expenditure in a metabolic chamber, and they know exactly what they're eating
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TABLE 2 Clinical outcomes of the selected cohort under investigation
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Researchers studying pure angiogenesis, ECM remodeling, or cytoprotection without inflammatory confounders should choose GLOW