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Women using oral contraceptives should be advised to consider non-oral or additional barrier contraception for 4 weeks after initiation and following each dose increase

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This chronic, painful disorder is strongly linked to obesity, insulin resistance, and systemic inflammation

Results take longer to appear but compliance is significantly higher because people do not quit from unbearable side effects

doi: 10.1007/s13562-016-0385-3 62 PogueG

However, only two appear to have been published in peer-reviewed journals to-date