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However, heterozygous adult ABCB4 carriers exhibit a wide range of clinical presentations

First, a substantial proportion of the mechanistic evidence is derived from animal models and in vitro studies, which may not fully capture the complexity of human liver physiology and disease pathogenesis

Source: Xie, Y., Choi, T

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Klein notes that, in the trial, GLP-1s appeared to help with opioid addictions in a similar fashion as food addictions, enabling users to better control resisting cravings and ultimately avoid addiction behaviors