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The result is a prolonged half-life of ~13 hours , making it suitable for once-daily injection ( [112] ) ( [113] )

The limited number of treatments able to significantly reduce weight, as well as the risk of renewed weight gain from 6 months after the end of intervention, have been an obstacle for considering pharmacological treatment for obesity in patients with PsO or HS.15 Approved and marketed drugs in SpainOrlistat Orlistat is an inhibitor of the gastric and pancreatic lipases that block hydrolysis of triacyl glycerides and absorption of fatty acids through the intestinal endothelium

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