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The primary concern when considering semaglutide for patients with hypothyroidism is the potential for interaction between the drug and the thyroid hormone replacement therapy commonly used to treat hypothyroidism

Retatrutide is expected to start working very quickly, with some people noticing reduced appetite within the first few days

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Side effects are rare and usually very mild, including slight pain at the injection site

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Pregnancy and breastfeeding: as an investigational medicine, retatrutide has not been studied in pregnancy or breastfeeding