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GLP1 users showed higher risks of vitamin D deficiency and lower ferritin levels than people treated with other diabetes medications such as SGLT2 and DPP4 inhibitors

C.et al (2024)

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one in the moderate renal impairment group treated with sulphonylureas and one in the ESRD group treated with insulin (Table 4)

This dual action, increasing fat breakdown while blocking fat formation, creates a metabolic environment that favors net fat loss even when caloric intake is not dramatically reduced

Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects