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doi: 10.1159/000118012

The CCK gene is located on chromosome 3p22.1 and is composed of 6 exons that generate two alternatively spliced mRNAs, both of which encode the same 115 amino acid preproprotein

Paul and Brady also note that various single-nucleotide polymorphisms (SNPs) may influence the efficacy and bioavailability, but that at this time there is neither sufficient clinical research in this area nor are tests for these SNPs commercially available

The Retatrutide starting dose is 2 mg once weekly, gradually increasing over several months to a target maintenance dose of 12 mg per week

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