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Karnes et al., 2014
This forms an iron-LRRK2 positive feedback loop that exacerbates dopaminergic neuron apoptosis (163)
181,182 The occurrence of disulfidptosis is primarily attributed to the elevated expression level of SLC7A11 in cells, which leads to excessive cystine uptake
Briefly, lysates of 1 10 6 cells were incubated with S-adenosylmethionine donor at 37 C for 2 h in a plate pre-coated with DNA substrate
Mutations in the CYBA gene account for approximately 5% of CGD cases
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