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ALCA, together with alpha-lipoic acid, was shown to improve mitochondrial energy metabolism and decrease oxidative stress leading to improved memory in aged rats [144, 145]
This could explain why infection of mice with oral Trepomnema denticola bacteria induces Tau hyperphosphorylation and A accumulation in mice in the hippocampus with neuronal loss (Wu et al., 2022), and why filtrates of Helicobacter pylori bacteria induce Tau hyperphosphorylation in mouse neuroblastoma cells and rat brains via GSK-3 activation (Wang et al., 2014)
10.1242/bio.035238 57 de Carvalho VelosoC.RodriguesV
Proc Natl Acad Sci USA 2004
Several studies confirm that glutathione has immuno-modulating properties as it supports the functions of the immune system by modulating its response to pathogens
Nonparametric permutation tests for functional neuroimaging: a primer with examples
