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The sequence was isolated in the 1970s from the cerebral venous blood of sleep-induced rabbits and characterised as a naturally occurring nonapeptide (PMID 560681)

J Mol.Histol

The tripeptide (glycine-histidine-lysine) binds a single copper(II) ion with a stability constant of log K = 16.44, making it one of the strongest naturally occurring copper chelates in human plasma [1]

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( 4 ) Specifically citing the above study, the 2024 paper reported patient outcomes were compared using spinal decompression to non-surgical treatment in patients with clinical and MRI-verified lumbar spinal stenosis