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Furthermore, research on the anti-proliferative and pro-apoptotic activities of TPL (PG490) in primary cultures of human prostate epithelial cells revealed that TPL could induce cell senescence at low concentrations and trigger apoptosis through the regulation of signaling pathways at higher concentrations (Kiviharju et al., 2002)

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Supporting this hypothesis, we observed that despite the more oxidised than expected cytosolic NADP redox state, it seems to be coupled with a remarkable robustness to perturbation by exogenous oxidants in both yeast and mammalian cells

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PBS at pH 7.4 accelerates deamidation of asparagine residues, a degradation pathway that reduces receptor agonist activity without changing the peptide's molecular weight