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Day 47 By the end of the first week, appetite changes often become more noticeable: You may feel full sooner when eating Because semaglutide slows how quickly food leaves your stomach, that fullness tends to last longer You might naturally start eating smaller portions without forcing it Some people still experience gastrointestinal side effects such as: Constipation Loose stools or diarrhea Heartburn or mild stomach upset For many, these improve as the body adjusts, especially when dosing starts low and increases gradually as directed by a clinician