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Mixed breed dogs can often be healthier too as they have a wider gene pool

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Substrate promiscuity and hyperoxidation susceptibility as potential driving forces for the co-evolution of Prx5-Type and Prx6-Type 1-Cys peroxiredoxin mechanisms

Additionally, the high levels of LA, low pH, hypoxia, and reactive oxygen species (ROS) prevalent in the TME can impair T cells and natural killer cells while polarizing tumor-associated macrophages into a pro-tumoral M2-like phenotype, collectively facilitating immune evasion [20]

Dysbiosis is closely associated with various metabolic diseases such as obesity (76), gout (77), NAFLD (78), insulin resistance, diabetes mellitus and its complications (79, 80)