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Clinical trials specifically using the arginate formulation would provide human pharmacokinetic data and efficacy endpoints

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However, cortical bone thickness was decreased in the semaglutide group ( P = 0.032), while no significant changes in bone microarchitecture or biomechanical strength were noted

Unlike the well-studied CagriSema combination (cagrilintide + semaglutide) with proven 15-25% weight loss results from Phase 3 trials, adding cagrilintide to tirzepatide remains completely unstudied

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