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Gastrointestinal side effect management is paramount, as nausea, vomiting, and diarrhea can lead to dehydration and electrolyte imbalances that may contribute to palpitations

The rate of GSH synthesis is dependent upon the availability of cysteine and the activity of the rate-limiting enzyme, -glutamylcysteine synthetase (also called glutamate-cysteine ligase, GCL)

The results showed that after treatment with varying concentrations of MT, cell viability significantly decreased in TRIP13-KO cells compared to H1703 cells (Fig

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The jump from 4mg to 8mg produces substantial additional benefit, while the jump from 8mg to 12mg shows somewhat diminishing returns

The most common side effects are nausea, vomiting, diarrhea, and constipation especially during dose increases