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Hepatic Steatosis : Recently, a sub-study of the phase 3 clinical trial SURPASS-3 showed that, among patients receiving metformin and/or SGLT2 inhibitors, the addition of tirzepatide (10 or 15 mg) as compared to insulin degludec was able to significantly reduce hepatic fat content (evaluated by magnetic resonance) after 52 weeks of treatment

They do this without harming other cells around them

Spending on glucagon-like peptide-1 receptor agonists among US adults, JAMA Network Open (2025) H.R.4818 treat and reduce obesity act of 2023, Congress.gov (2023) Anti-obesity drugs will not be covered by Medicare and Medicaid in 2026, American College of Gastroenterology (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Do these peptides have side effects

AZD9550 and LY3305677 are GLP-1R and GCGR dual agonists in the early stages of clinical trials, being investigated as novel therapeutic options for the treatment of obesity

Peptide Hormone Exendin-4 Stimulates Subventricular Zone Neurogenesis in the Adult Rodent Brain and Induces Recovery in an Animal Model of Parkinsons Disease